Pharmaceutics 2010, 2(2), 224-244; doi:10.3390/pharmaceutics2020224
Article

The Role of Configurational Entropy in Amorphous Systems

Kirsten A. Graeser 1,2 , James E. Patterson 2 , J. Axel Zeitler 3  and Thomas Rades 1,* email
1 School of Pharmacy, University of Otago, Dunedin, New Zealand 2 Pharmaceutical Development, GlaxoSmithKline, Harlow, CM19 5AW, UK 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
* Author to whom correspondence should be addressed.
Received: 30 March 2010; in revised form: 18 May 2010 / Accepted: 21 May 2010 / Published: 25 May 2010
PDF Full-text Download PDF Full-Text [347 KB, uploaded 25 May 2010 13:34 CEST]
Abstract: Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
Keywords: configurational entropy; amorphous; molecular mobility; solubility

Supplementary Files

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Graeser, K.A.; Patterson, J.E.; Zeitler, J.A.; Rades, T. The Role of Configurational Entropy in Amorphous Systems. Pharmaceutics 2010, 2, 224-244.

AMA Style

Graeser KA, Patterson JE, Zeitler JA, Rades T. The Role of Configurational Entropy in Amorphous Systems. Pharmaceutics. 2010; 2(2):224-244.

Chicago/Turabian Style

Graeser, Kirsten A.; Patterson, James E.; Zeitler, J. Axel; Rades, Thomas. 2010. "The Role of Configurational Entropy in Amorphous Systems." Pharmaceutics 2, no. 2: 224-244.

Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert