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The Role of Configurational Entropy in Amorphous Systems
School of Pharmacy, University of Otago, Dunedin, New Zealand
Pharmaceutical Development, GlaxoSmithKline, Harlow, CM19 5AW, UK
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
* Author to whom correspondence should be addressed.
Received: 30 March 2010; in revised form: 18 May 2010 / Accepted: 21 May 2010 / Published: 25 May 2010
Abstract: Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
Keywords: configurational entropy; amorphous; molecular mobility; solubility
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MDPI and ACS Style
Graeser, K.A.; Patterson, J.E.; Zeitler, J.A.; Rades, T. The Role of Configurational Entropy in Amorphous Systems. Pharmaceutics 2010, 2, 224-244.
Graeser KA, Patterson JE, Zeitler JA, Rades T. The Role of Configurational Entropy in Amorphous Systems. Pharmaceutics. 2010; 2(2):224-244.
Graeser, Kirsten A.; Patterson, James E.; Zeitler, J. Axel; Rades, Thomas. 2010. "The Role of Configurational Entropy in Amorphous Systems." Pharmaceutics 2, no. 2: 224-244.