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Pharmaceutics 2010, 2(2), 224-244; doi:10.3390/pharmaceutics2020224

The Role of Configurational Entropy in Amorphous Systems

1,2, 2, 3 and 1,*
1 School of Pharmacy, University of Otago, Dunedin, New Zealand 2 Pharmaceutical Development, GlaxoSmithKline, Harlow, CM19 5AW, UK 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
* Author to whom correspondence should be addressed.
Received: 30 March 2010 / Revised: 18 May 2010 / Accepted: 21 May 2010 / Published: 25 May 2010
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Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
Keywords: configurational entropy; amorphous; molecular mobility; solubility configurational entropy; amorphous; molecular mobility; solubility
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Graeser, K.A.; Patterson, J.E.; Zeitler, J.A.; Rades, T. The Role of Configurational Entropy in Amorphous Systems. Pharmaceutics 2010, 2, 224-244.

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