Pharmaceutics 2010, 2(2), 209-223; doi:10.3390/pharmaceutics2020209
Article

A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells

Received: 18 March 2010; in revised form: 2 April 2010 / Accepted: 17 May 2010 / Published: 18 May 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Synthetic membranes used in Franz diffusion cells for topical formulation quality assessment should provide least resistance to drug diffusion. In this study, the diffusion rates of ibuprofen across thirteen membranes were determined using Franz diffusion cells. Correlation of the membrane thickness, pore size and MWCO with drug fluxes was also made. The drug diffusion results showed that the porous membranes were categorized into high-flux (8–18 mg/cm2/h) and low-flux (0.1–3 mg/cm2/h) membranes. The drug fluxes did not show strong correlations (r2 < 0.99) with membrane parameters. Synthetic membranes can give variable drug fluxes, thus investigators should be careful in choosing membrane for formulation quality assessment.
Keywords: Franz diffusion cells; synthetic membranes; ibuprofen drug diffusion; transdermal absorption; in vitro absorption
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MDPI and ACS Style

Ng, S.-F.; Rouse, J.; Sanderson, D.; Eccleston, G. A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells. Pharmaceutics 2010, 2, 209-223.

AMA Style

Ng S-F, Rouse J, Sanderson D, Eccleston G. A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells. Pharmaceutics. 2010; 2(2):209-223.

Chicago/Turabian Style

Ng, Shiow-Fern; Rouse, Jennifer; Sanderson, Dominic; Eccleston, Gillian. 2010. "A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells." Pharmaceutics 2, no. 2: 209-223.

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