Pharmaceutics 2010, 2(2), 209-223; doi:10.3390/pharmaceutics2020209
Article

A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells

Shiow-Fern Ng 1,* email, Jennifer Rouse 2 , Dominic Sanderson 3  and Gillian Eccleston 2
1 Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia 2 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Taylor Street, Glasgow G4 0NR, UK 3 GlaxoSmithKline, Pharmaceutical Development, Harlow, CM19 5AW, UK
* Author to whom correspondence should be addressed.
Received: 18 March 2010; in revised form: 2 April 2010 / Accepted: 17 May 2010 / Published: 18 May 2010
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Abstract: Synthetic membranes used in Franz diffusion cells for topical formulation quality assessment should provide least resistance to drug diffusion. In this study, the diffusion rates of ibuprofen across thirteen membranes were determined using Franz diffusion cells. Correlation of the membrane thickness, pore size and MWCO with drug fluxes was also made. The drug diffusion results showed that the porous membranes were categorized into high-flux (8–18 mg/cm2/h) and low-flux (0.1–3 mg/cm2/h) membranes. The drug fluxes did not show strong correlations (r2 < 0.99) with membrane parameters. Synthetic membranes can give variable drug fluxes, thus investigators should be careful in choosing membrane for formulation quality assessment.
Keywords: Franz diffusion cells; synthetic membranes; ibuprofen drug diffusion; transdermal absorption; in vitro absorption

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MDPI and ACS Style

Ng, S.-F.; Rouse, J.; Sanderson, D.; Eccleston, G. A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells. Pharmaceutics 2010, 2, 209-223.

AMA Style

Ng S-F, Rouse J, Sanderson D, Eccleston G. A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells. Pharmaceutics. 2010; 2(2):209-223.

Chicago/Turabian Style

Ng, Shiow-Fern; Rouse, Jennifer; Sanderson, Dominic; Eccleston, Gillian. 2010. "A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells." Pharmaceutics 2, no. 2: 209-223.

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