Pharmaceutics 2010, 2(2), 245-257; doi:10.3390/pharmaceutics2020245

Useful Extend-release Chitosan Tablets with High Antioxidant Activity

1,†, 1,†, 1, 1, 1, 2 and 1,* email
Received: 6 May 2010; in revised form: 21 May 2010 / Accepted: 26 May 2010 / Published: 27 May 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The antioxidant properties of different low molecular weight (LMW) chitosans (CS1; 22 kDa, CS2; 38 kDa, CS3; 52 kDa, CS4; 81 kDa) were examined for possible use in extended-release tablets. The criteria used were the ability of the chitosans to reduce Cu2+, and hydroxyl and superoxide radicals and N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl, via the use of ESR spectrometry. CS2 showed the highest scavenging activity. CS1 and CS3, however, were much less effective and CS4 was not a viable antioxidant. The results suggest that CS2 could be useful in combating the development of oxidative stress. A series of chitosan tablets were prepared using a spray drying method and evaluated as an extended-release matrix tablet using theophylline (TPH) as a model drug. The release of TPH from the different MW chitosan tablets increased with increasing MW of the chitosan used. CS2, CS3 and CS4 showed a reasonable release activity, but CS1 showed the shortest release activity. Moreover, the CS2-TPH tablet showed the highest scavenging activity of the three chitosan tablets (CS2-CS4) using 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radicals. These results suggest that a CS2-TPH tablet could be potentially useful in an extended-release matrix tablet with a high antioxidant activity.
Keywords: chitosan; antioxidant; molecular weight; matrix tablet; extend-release; radicals
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MDPI and ACS Style

Yasufuku, T.; Anraku, M.; Kondo, Y.; Hata, T.; Hirose, J.; Kobayashi, N.; Tomida, H. Useful Extend-release Chitosan Tablets with High Antioxidant Activity. Pharmaceutics 2010, 2, 245-257.

AMA Style

Yasufuku T, Anraku M, Kondo Y, Hata T, Hirose J, Kobayashi N, Tomida H. Useful Extend-release Chitosan Tablets with High Antioxidant Activity. Pharmaceutics. 2010; 2(2):245-257.

Chicago/Turabian Style

Yasufuku, Taira; Anraku, Makoto; Kondo, Yuko; Hata, Toshiyuki; Hirose, Junzo; Kobayashi, Nobuyuki; Tomida, Hisao. 2010. "Useful Extend-release Chitosan Tablets with High Antioxidant Activity." Pharmaceutics 2, no. 2: 245-257.

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