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Pharmaceutics 2018, 10(3), 93; https://doi.org/10.3390/pharmaceutics10030093

New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort

1
Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Chía, Colombia
2
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, 110231 Bogotá, Colombia
3
Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, 7500912 Santiago, Chile
4
Instituto de Genética, Facultad de Medicina, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, 110231 Bogotá, Colombia
*
Author to whom correspondence should be addressed.
Received: 29 May 2018 / Revised: 9 July 2018 / Accepted: 11 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue ABC Transporter-Mediated Drug Disposition)
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Abstract

Multidrug resistance-associated proteins (MRP) 1 and 2 belong to the ABC (ATP-Binding Cassette) transporters. These transport proteins are involved in the removal of various drugs and xenobiotics, as well as in multiple physiological, pathological, and pharmacological processes. There is a strong correlation between different polymorphisms and their clinical implication in resistance to antiepileptic drugs, anticancer, and anti-infective agents. In our study, we evaluated exon regions of MRP1 (ABCC1)/MRP2 (ABCC2) in a Colombian cohort of healthy subjects to determine single nucleotide polymorphisms (SNPs) and to determine the allelic and genomic frequency. Results showed there are SNPs in our population that have been previously reported for both MRP1/ABCC1 (rs200647436, rs200624910, rs150214567) and MRP2/ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Additionally, 13 new SNPs were identified. Evidence also shows a significant clinical correlation for polymorphisms rs3740066 and rs2273697 in the transport of multiple drugs, which suggests a genetic variability in regards to that reported in other populations. View Full-Text
Keywords: ATP-Binding-cassette (ABC); MRP1 and MRP2; polymorphisms; drug resistance; genetic variability ATP-Binding-cassette (ABC); MRP1 and MRP2; polymorphisms; drug resistance; genetic variability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Bustos-Cruz, R.H.; Martínez, L.R.; García, J.C.; Barreto, G.E.; Suárez, F. New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort. Pharmaceutics 2018, 10, 93.

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