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Pharmaceutics 2018, 10(3), 92; https://doi.org/10.3390/pharmaceutics10030092

Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Chao Qin and Xiaofei Xin contributed equally to this work.
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Received: 7 June 2018 / Revised: 2 July 2018 / Accepted: 4 July 2018 / Published: 13 July 2018
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Abstract

Amorphous nanosuspensions (ANSs) enable rapid release and improved delivery of a poorly water-soluble drug; however, their preparation is challenging. Here, using hemoglobin (Hb) as a carrier, ANSs aggregated from paclitaxel (PTX)–Hb complexes were prepared to improve delivery of the hydrophobic anti-cancer agent. An affinity study demonstrated strong interaction between Hb and PTX. Importantly, the complexes could aggregate into <300 nm ANSs with high drug loading, which acidic condition facilitated their formation. Furthermore, the ANSs possessed improved cytotoxicity against cancer cells over the crystalline nanosuspensions. Taken together, ANSs aggregated from PTX–Hb complexes were developed, which could kill cancer cells with high efficiency. View Full-Text
Keywords: nanosuspensions; amorphous; affinity; drug-protein complexes; cytotoxicity nanosuspensions; amorphous; affinity; drug-protein complexes; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Qin, C.; Xin, X.; Pei, X.; Yin, L.; He, W. Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity. Pharmaceutics 2018, 10, 92.

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