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Pharmaceutics 2018, 10(3), 91; https://doi.org/10.3390/pharmaceutics10030091

Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells

LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr Roberto Frias, 4200-465 Porto, Portugal
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Received: 3 May 2018 / Revised: 6 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
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Abstract

Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported. View Full-Text
Keywords: gold nanoparticles; tyrosine conjugation; pancreatic cells gold nanoparticles; tyrosine conjugation; pancreatic cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Coelho, S.C.; Reis, D.P.; Pereira, M.C.; Coelho, M.A.N. Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells. Pharmaceutics 2018, 10, 91.

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