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Viruses 2017, 9(9), 246; doi:10.3390/v9090246

The Mouse Papillomavirus Infection Model

1
The Jake Gittlen Laboratories for Cancer Research, Hershey, PA 17033, USA
2
Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
3
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Alison A. McBride and Karl Munger
Received: 7 August 2017 / Revised: 23 August 2017 / Accepted: 24 August 2017 / Published: 30 August 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
View Full-Text   |   Download PDF [2029 KB, uploaded 30 August 2017]   |  

Abstract

The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and immunological mechanisms of MmuPV1 infections in both immunocompromised and immunocompetent hosts. This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. The model is a major step forward in the study of papillomavirus disease and pathology. In this review, we summarize studies using MmuPV1 over the past six years and share our perspectives on the value of this unique model system. Specifically, we discuss viral pathogenesis in cutaneous and mucosal tissues as well as in different mouse strains, immune responses to the virus, and local host-restricted factors that may be involved in MmuPV1 infections and associated disease progression. View Full-Text
Keywords: the mouse papillomavirus; tissue tropism; anogenital; oral infection; skin carcinoma; pathogenesis; innate immunity; adaptive immunity; RNA sequencing; host defense the mouse papillomavirus; tissue tropism; anogenital; oral infection; skin carcinoma; pathogenesis; innate immunity; adaptive immunity; RNA sequencing; host defense
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hu, J.; Cladel, N.M.; Budgeon, L.R.; Balogh, K.K.; Christensen, N.D. The Mouse Papillomavirus Infection Model. Viruses 2017, 9, 246.

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