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Viruses 2017, 9(9), 241; doi:10.3390/v9090241

Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis

1
The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
2
Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, Ctra. de la Coruña Km 7.5, 28040 Madrid, Spain
Current Address: Pathology Department, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone KT15 3NB, UK.
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Kvansakul
Received: 3 August 2017 / Revised: 18 August 2017 / Accepted: 21 August 2017 / Published: 25 August 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
View Full-Text   |   Download PDF [1885 KB, uploaded 25 August 2017]   |  

Abstract

African swine fever virus (ASFV) is a large DNA virus that replicates predominantly in the cell cytoplasm and is the only member of the Asfarviridae family. The virus causes an acute haemorrhagic fever, African swine fever (ASF), in domestic pigs and wild boar resulting in the death of most infected animals. Apoptosis is induced at an early stage during virus entry or uncoating. However, ASFV encodes anti-apoptotic proteins which facilitate production of progeny virions. These anti-apoptotic proteins include A179L, a Bcl-2 family member; A224L, an inhibitor of apoptosis proteins (IAP) family member; EP153R a C-type lectin; and DP71L. The latter acts by inhibiting activation of the stress activated pro-apoptotic pathways pro-apoptotic pathways. The mechanisms by which these proteins act is summarised. ASF disease is characterised by massive apoptosis of uninfected lymphocytes which reduces the effectiveness of the immune response, contributing to virus pathogenesis. Mechanisms by which this apoptosis is induced are discussed. View Full-Text
Keywords: African swine fever virus; apoptosis; A179L; A224L pathogenesis African swine fever virus; apoptosis; A179L; A224L pathogenesis
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Dixon, L.K.; Sánchez-Cordón, P.J.; Galindo, I.; Alonso, C. Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis. Viruses 2017, 9, 241.

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