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Viruses 2017, 9(7), 179; doi:10.3390/v9070179

Development of Polioencephalomyelitis in Cesarean-Derived Colostrum-Deprived Pigs Following Experimental Inoculation with Either Teschovirus A Serotype 2 or Serotype 11

Veterinary Diagnostic Laboratory, Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1850 Christensen Drive, Ames, IA 50011-1134, USA
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Academic Editor: Andrew Mehle
Received: 15 May 2017 / Revised: 20 June 2017 / Accepted: 27 June 2017 / Published: 8 July 2017
(This article belongs to the Section Animal Viruses)
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Abstract

Teschovirus encephalomyelitis is a sporadic disease associated with Teschovirus A (PTV) serotype 1 and, less frequently, other serotypes. In recent years, the number of cases submitted to the Iowa State University Veterinary Diagnostic Laboratory with a history of posterior paresis has increased. Submission histories from various regions of the United States suggest a trend for clinical disease to persist in herds and affect a wider age-range of pigs than historically reported. Polioencephalitis and/or myelitis was consistently present and PTV was detected in affected neural tissue by PCR in a portion of cases. Sequencing from two clinical cases identified PTV-2 and PTV-11. To assess neuropathogenicity of these isolates, 5-week-old cesarean derived and colostrum-deprived pigs were assigned to three groups: negative control (n = 4), PTV-2-inoculated (n = 7), and PTV-11-inoculated (n = 7). Three PTV-2-inoculated pigs developed mild incoordination of the hind limbs, one of which progressed to posterior ataxia. While all PTV-11-inoculated pigs showed severe neurological signs consistent with Teschovirus encephalomyelitis, no evidences of neurological signs were observed in sham-inoculated animals. All PTV-2- and PTV-11-inoculated pigs had microscopic lesions consistent with Teschovirus encephalomyelitis. To our knowledge, this is the first description of PTV-11 and experimental study demonstrating the neuropathogenicity of PTV-11 in the United States. View Full-Text
Keywords: Teschovirus encephalomyelitis; Teschovirus A; Porcine teschovirus; Porcine teschovirus 2; Porcine teschovirus 11; poliomyelitis; Teschen disease; Talfan disease Teschovirus encephalomyelitis; Teschovirus A; Porcine teschovirus; Porcine teschovirus 2; Porcine teschovirus 11; poliomyelitis; Teschen disease; Talfan disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Matias Ferreyra, F.; Arruda, B.; Stevenson, G.; Schwartz, K.; Madson, D.; Yoon, K.-J.; Zhang, J.; Piñeyro, P.; Chen, Q.; Arruda, P. Development of Polioencephalomyelitis in Cesarean-Derived Colostrum-Deprived Pigs Following Experimental Inoculation with Either Teschovirus A Serotype 2 or Serotype 11. Viruses 2017, 9, 179.

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