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Viruses 2017, 9(6), 128; doi:10.3390/v9060128

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

1,†,* , 1,†
and
2,*
1
Department of Virology, Faculty of Veterinary Medicine, Uludag University, TR-16059 Bursa, Turkey
2
Institute for Virology, Department of Infectious Diseases, University of Veterinary Medicine, D-30559 Hannover, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 3 May 2017 / Revised: 18 May 2017 / Accepted: 19 May 2017 / Published: 26 May 2017
(This article belongs to the Section Animal Viruses)
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Abstract

Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and distributed on all of the continents. BVDV-1 can be segregated into at least twenty-one subgenotypes (1a–1u), while four subgenotypes have been described for BVDV-2 (2a–2d). With respect to published sequences, the number of virus isolates described for BVDV-1 (88.2%) is considerably higher than for BVDV-2 (11.8%). The most frequently-reported BVDV-1 subgenotype are 1b, followed by 1a and 1c. The highest number of various BVDV subgenotypes has been documented in European countries, indicating greater genetic diversity of the virus on this continent. Current segregation of BVDV field isolates and the designation of subgenotypes are not harmonized. While the species BVDV-1 and BVDV-2 can be clearly differentiated independently from the portion of the genome being compared, analysis of different genomic regions can result in inconsistent assignment of some BVDV isolates to defined subgenotypes. To avoid non-conformities the authors recommend the development of a harmonized system for subdivision of BVDV isolates into defined subgenotypes. View Full-Text
Keywords: bovine viral diarrhea virus; epidemiology; global distribution; genetic diversity; subgenotyping bovine viral diarrhea virus; epidemiology; global distribution; genetic diversity; subgenotyping
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yeşilbağ, K.; Alpay, G.; Becher, P. Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus. Viruses 2017, 9, 128.

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