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Viruses 2017, 9(5), 100; doi:10.3390/v9050100

Regulated Entry of Hepatitis C Virus into Hepatocytes

1
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
2
Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Jens H. Kuhn
Received: 21 March 2017 / Revised: 24 April 2017 / Accepted: 2 May 2017 / Published: 9 May 2017
(This article belongs to the Section Animal Viruses)
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Abstract

Hepatitis C virus (HCV) is a model for the study of virus–host interaction and host cell responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and this process requires multiple receptors working together. The scavenger receptor class B type I (SR-BI) and claudin-1 (CLDN1), together with human cluster of differentiation (CD) 81 and occludin (OCLN), constitute the minimal set of HCV entry receptors. Nevertheless, HCV entry is a complex process involving multiple host signaling pathways that form a systematic regulatory network; this network is centrally controlled by upstream regulators epidermal growth factor receptor (EGFR) and transforming growth factor β receptor (TGFβ-R). Further feedback regulation and cell-to-cell spread of the virus contribute to the chronic maintenance of HCV infection. A comprehensive and accurate disclosure of this critical process should provide insights into the viral entry mechanism, and offer new strategies for treatment regimens and targets for HCV therapeutics. View Full-Text
Keywords: hepatitis C virus; cell entry; regulation; signaling; receptor hepatitis C virus; cell entry; regulation; signaling; receptor
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Miao, Z.; Xie, Z.; Miao, J.; Ran, J.; Feng, Y.; Xia, X. Regulated Entry of Hepatitis C Virus into Hepatocytes. Viruses 2017, 9, 100.

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