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Viruses 2017, 9(4), 85; doi:10.3390/v9040085

Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis

1
Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, 4000 Liege, Belgium
2
Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Received: 27 March 2017 / Revised: 13 April 2017 / Accepted: 18 April 2017 / Published: 20 April 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
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Abstract

Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre)cancers. The present review summarizes the current knowledge on junctional cells, discusses their high vulnerability to HPV infection, and stresses the potential clinical/translational value of the novel dualistic model of HPV-related carcinogenesis. View Full-Text
Keywords: human papillomavirus; squamo-columnar junctions; (pre)neoplastic lesions human papillomavirus; squamo-columnar junctions; (pre)neoplastic lesions
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Herfs, M.; Soong, T.R.; Delvenne, P.; Crum, C.P. Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis. Viruses 2017, 9, 85.

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