Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells
AbstractOncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as present in sub-regions of HPV-positive cancers, strongly affect the interplay between the HPV oncogenes and their transformed host cell. As a result, a state of dormancy is induced in hypoxic HPV-positive cancer cells, which is characterized by a shutdown of viral oncogene expression and a proliferative arrest that can be reversed by reoxygenation. In this review, these findings are put into the context of the current concepts of both HPV-linked carcinogenesis and of the effects of hypoxia on tumor biology. Moreover, we discuss the consequences for the phenotype of HPV-positive cancer cells as well as for their clinical behavior and response towards established and prospective therapeutic strategies. View Full-Text
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Hoppe-Seyler, K.; Mändl, J.; Adrian, S.; Kuhn, B.J.; Hoppe-Seyler, F. Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells. Viruses 2017, 9, 174.
Hoppe-Seyler K, Mändl J, Adrian S, Kuhn BJ, Hoppe-Seyler F. Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells. Viruses. 2017; 9(7):174.Chicago/Turabian Style
Hoppe-Seyler, Karin; Mändl, Julia; Adrian, Svenja; Kuhn, Bianca J.; Hoppe-Seyler, Felix. 2017. "Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells." Viruses 9, no. 7: 174.
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