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Viruses 2017, 9(2), 32; doi:10.3390/v9020032

HCIV-1 and Other Tailless Icosahedral Internal Membrane-Containing Viruses of the Family Sphaerolipoviridae

1
Department of Biosciences and Institute of Biotechnology, Viikinkaari 9, FIN-00014, University of Helsinki, Helsinki, Finland
2
Department of Food and Environmental Sciences, Viikinkaari 9, FIN-00014, University of Helsinki, Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editors: Tessa E.F. Quax, Matthias G. Fischer and Laurent Debarbieux
Received: 10 January 2017 / Revised: 10 January 2017 / Accepted: 13 February 2017 / Published: 18 February 2017
(This article belongs to the Special Issue Viruses of Microbes)
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Abstract

Members of the virus family Sphaerolipoviridae include both archaeal viruses and bacteriophages that possess a tailless icosahedral capsid with an internal membrane. The genera Alpha- and Betasphaerolipovirus comprise viruses that infect halophilic euryarchaea, whereas viruses of thermophilic Thermus bacteria belong to the genus Gammasphaerolipovirus. Both sequence-based and structural clustering of the major capsid proteins and ATPases of sphaerolipoviruses yield three distinct clades corresponding to these three genera. Conserved virion architectural principles observed in sphaerolipoviruses suggest that these viruses belong to the PRD1-adenovirus structural lineage. Here we focus on archaeal alphasphaerolipoviruses and their related putative proviruses. The highest sequence similarities among alphasphaerolipoviruses are observed in the core structural elements of their virions: the two major capsid proteins, the major membrane protein, and a putative packaging ATPase. A recently described tailless icosahedral haloarchaeal virus, Haloarcula californiae icosahedral virus 1 (HCIV-1), has a double-stranded DNA genome and an internal membrane lining the capsid. HCIV-1 shares significant similarities with the other tailless icosahedral internal membrane-containing haloarchaeal viruses of the family Sphaerolipoviridae. The proposal to include a new virus species, Haloarcula virus HCIV1, into the genus Alphasphaerolipovirus was submitted to the International Committee on Taxonomy of Viruses (ICTV) in 2016. View Full-Text
Keywords: Sphaerolipoviridae; Alphasphaerolipovirus; halovirus; archaeal virus; tailless icosahedral virus; membrane virus; halophilic archaea; virus classification; International Committee on Taxonomy of Viruses; structure-based viral lineage Sphaerolipoviridae; Alphasphaerolipovirus; halovirus; archaeal virus; tailless icosahedral virus; membrane virus; halophilic archaea; virus classification; International Committee on Taxonomy of Viruses; structure-based viral lineage
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MDPI and ACS Style

Demina, T.A.; Pietilä, M.K.; Svirskaitė, J.; Ravantti, J.J.; Atanasova, N.S.; Bamford, D.H.; Oksanen, H.M. HCIV-1 and Other Tailless Icosahedral Internal Membrane-Containing Viruses of the Family Sphaerolipoviridae. Viruses 2017, 9, 32.

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