Next Article in Journal
Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins
Previous Article in Journal
Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
Previous Article in Special Issue
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus
Article Menu

Export Article

Open AccessReview
Viruses 2017, 9(10), 290; doi:10.3390/v9100290

The Bcl-2 Family in Host-Virus Interactions

1
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
2
Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
*
Authors to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 1 October 2017 / Accepted: 3 October 2017 / Published: 6 October 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
View Full-Text   |   Download PDF [1749 KB, uploaded 11 October 2017]   |  

Abstract

Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections. View Full-Text
Keywords: Bcl-2; apoptosis; autophagy; structural biology; poxvirus; herpesvirus; asfarvirus; iridovirus; adenovirus; host-pathogen interactions Bcl-2; apoptosis; autophagy; structural biology; poxvirus; herpesvirus; asfarvirus; iridovirus; adenovirus; host-pathogen interactions
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kvansakul, M.; Caria, S.; Hinds, M.G. The Bcl-2 Family in Host-Virus Interactions. Viruses 2017, 9, 290.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top