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Viruses 2017, 9(1), 24; doi:10.3390/v9010024

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

1
Department of Biosciences, University of Helsinki, Helsinki FIN-00014, Finland
2
Department of Chemistry and Biochemistry, University of Bern, Bern CH-3012, Switzerland
3
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editors: Robert Hogg and Karen L. Beemon
Received: 18 November 2016 / Revised: 5 January 2017 / Accepted: 13 January 2017 / Published: 23 January 2017
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
View Full-Text   |   Download PDF [2459 KB, uploaded 23 January 2017]   |  

Abstract

Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD. View Full-Text
Keywords: RNA quality control; gene expression; translation; RNA-protein interactions RNA quality control; gene expression; translation; RNA-protein interactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Balistreri, G.; Bognanni, C.; Mühlemann, O. Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses 2017, 9, 24.

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