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Viruses 2017, 9(1), 14; doi:10.3390/v9010014

The IMPORTance of the Nucleus during Flavivirus Replication

1
Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia
2
Department of Physiology, Anatomy & Microbiology, La Trobe University, Melbourne 3086, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Holbrook
Received: 16 December 2016 / Revised: 10 January 2017 / Accepted: 12 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
View Full-Text   |   Download PDF [791 KB, uploaded 19 January 2017]   |  

Abstract

Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome consists of positive sense RNA, replication can occur wholly within the cytoplasm. What is becoming more evident is that some viral proteins also have the ability to translocate to the nucleus, with potential roles in replication and immune system perturbation. In this review, we discuss the current understanding of flavivirus nuclear localisation, and the function it has during flavivirus infection. We also describe—while closely related—the functional differences between similar viral proteins in their nuclear translocation. View Full-Text
Keywords: flavivirus; nucleus; transport; karyopherins; nuclear pore complex; nuclear localisation sequence flavivirus; nucleus; transport; karyopherins; nuclear pore complex; nuclear localisation sequence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lopez-Denman, A.J.; Mackenzie, J.M. The IMPORTance of the Nucleus during Flavivirus Replication. Viruses 2017, 9, 14.

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