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Viruses 2016, 8(9), 251; doi:10.3390/v8090251

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

Institute for Biomedical Sciences, Georgia State University, 100 Piedmont Av, Atlanta, GA 30303, USA
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Author to whom correspondence should be addressed.
Academic Editor: Eric Freed
Received: 3 August 2016 / Revised: 2 September 2016 / Accepted: 5 September 2016 / Published: 10 September 2016
(This article belongs to the Special Issue Recent Progress in Measles Virus Research)
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Abstract

The morbillivirus genus comprises major human and animal pathogens, including the highly contagious measles virus. Morbilliviruses feature single stranded negative sense RNA genomes that are wrapped by a plasma membrane-derived lipid envelope. Genomes are encapsidated by the viral nucleocapsid protein forming ribonucleoprotein complexes, and only the encapsidated RNA is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRp). In this review, we discuss recent breakthroughs towards the structural and functional understanding of the morbillivirus polymerase complex. Considering the clinical burden imposed by members of the morbillivirus genus, the development of novel antiviral therapeutics is urgently needed. The viral polymerase complex presents unique structural and enzymatic properties that can serve as attractive candidates for druggable targets. We evaluate distinct strategies for therapeutic intervention and examine how high-resolution insight into the organization of the polymerase complex may pave the path towards the structure-based design and optimization of next-generation RdRp inhibitors. View Full-Text
Keywords: measles virus; morbillivirus; viral polymerase; antiviral drug; polymerase inhibitor measles virus; morbillivirus; viral polymerase; antiviral drug; polymerase inhibitor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sourimant, J.; Plemper, R.K. Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex. Viruses 2016, 8, 251.

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