Next Article in Journal / Special Issue
A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus
Previous Article in Journal
Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins
Previous Article in Special Issue
Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic Hepatitis
Article Menu

Export Article

Open AccessReview
Viruses 2016, 8(8), 229; doi:10.3390/v8080229

Role of Envelopment in the HEV Life Cycle

1
,
1
and
1,2,*
1
Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA
2
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jacques Izopet
Received: 30 June 2016 / Revised: 2 August 2016 / Accepted: 11 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Recent Progress in Hepatitis E Virus Research)
View Full-Text   |   Download PDF [895 KB, uploaded 18 August 2016]   |  

Abstract

Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient’s blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity. View Full-Text
Keywords: hepatitis E virus; quasi-envelopment hepatitis E virus; quasi-envelopment
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yin, X.; Li, X.; Feng, Z. Role of Envelopment in the HEV Life Cycle. Viruses 2016, 8, 229.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top