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Viruses 2016, 8(6), 178; doi:10.3390/v8060178

Marburg Virus Reverse Genetics Systems

1
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems 17493, Germany
2
Department of Microbiology, School of Medicine, Boston University, 620 Albany Street, Boston, MA 02118, USA
3
National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, 620 Albany Street, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Luis Martinez-Sobrido
Received: 9 May 2016 / Revised: 14 June 2016 / Accepted: 16 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Replication-Competent Reporter-Expressing Viruses)
View Full-Text   |   Download PDF [1141 KB, uploaded 22 June 2016]   |  

Abstract

The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image viral infection, and screen for antivirals. This article provides an overview of the currently established MARV reverse genetic systems based on minigenomes, infectious virus-like particles and full-length clones, and the research that has been conducted using these systems. View Full-Text
Keywords: Marburg virus; Ebola virus; filoviruses; nonsegmented negative-sense RNA viruses; reverse genetics system; minigenome; full-length clones; virus-like particles; virus rescue; biosafety level 4 Marburg virus; Ebola virus; filoviruses; nonsegmented negative-sense RNA viruses; reverse genetics system; minigenome; full-length clones; virus-like particles; virus rescue; biosafety level 4
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Schmidt, K.M.; Mühlberger, E. Marburg Virus Reverse Genetics Systems. Viruses 2016, 8, 178.

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