Next Article in Journal
Antiviral Hammerhead Ribozymes Are Effective for Developing Transgenic Suppression of Chikungunya Virus in Aedes aegypti Mosquitoes
Next Article in Special Issue
Phleboviruses and the Type I Interferon Response
Previous Article in Journal
Recombinant Sheep Pox Virus Proteins Elicit Neutralizing Antibodies
Previous Article in Special Issue
Mutational Analysis of the Rift Valley Fever Virus Glycoprotein Precursor Proteins for Gn Protein Expression
Article Menu

Export Article

Open AccessArticle
Viruses 2016, 8(6), 164; doi:10.3390/v8060164

Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae)

1
Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA
2
Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
3
Galveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
4
Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
5
School of Medicine, New York University, New York, NY 10016, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jane Tao and Pierre-Yves Lozach
Received: 2 April 2016 / Revised: 25 May 2016 / Accepted: 26 May 2016 / Published: 10 June 2016
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
View Full-Text   |   Download PDF [3413 KB, uploaded 10 June 2016]   |  

Abstract

Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wēnzhōu tick virus, Huángpí tick virus 1, Tǎchéng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shāyáng spider virus 1, Xīnzhōu spider virus, Sānxiá water strider virus 1, South Bay virus, Wǔhàn millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup. View Full-Text
Keywords: Bunyaviridae; bunyavirus; nairovirus; Dera Ghazi Khan virus; Erve virus; Ganjam virus; Hughes virus; Qalyub virus; Sakhalin virus; Tunis virus; virus classification; virus taxonomy Bunyaviridae; bunyavirus; nairovirus; Dera Ghazi Khan virus; Erve virus; Ganjam virus; Hughes virus; Qalyub virus; Sakhalin virus; Tunis virus; virus classification; virus taxonomy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kuhn, J.H.; Wiley, M.R.; Rodriguez, S.E.; Bào, Y.; Prieto, K.; Travassos da Rosa, A.P.A.; Guzman, H.; Savji, N.; Ladner, J.T.; Tesh, R.B.; Wada, J.; Jahrling, P.B.; Bente, D.A.; Palacios, G. Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae). Viruses 2016, 8, 164.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top