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Viruses 2015, 7(6), 3116-3129; doi:10.3390/v7062762

Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
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Author to whom correspondence should be addressed.
Academic Editor: Andrew Mehle
Received: 27 April 2015 / Accepted: 11 June 2015 / Published: 16 June 2015
(This article belongs to the Special Issue Gene Technology and Resistance to Viruses - Reviews)
View Full-Text   |   Download PDF [477 KB, uploaded 16 June 2015]   |  

Abstract

The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced by IL-32 and its associated regulatory mechanisms. The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described. This review aims to integrate these new findings into explicit concepts and raises the intriguing possibility of IL-32 as a therapeutic target. View Full-Text
Keywords: interleukin-32; pro-inflammatory cytokine; virus infection; antiviral activities interleukin-32; pro-inflammatory cytokine; virus infection; antiviral activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhou, Y.; Zhu, Y. Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection. Viruses 2015, 7, 3116-3129.

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