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Viruses 2015, 7(12), 6291-6312; doi:10.3390/v7122938

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK
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Author to whom correspondence should be addressed.
Academic Editors: Martine Lamfers and E. Antonio Chiocca
Received: 24 September 2015 / Revised: 20 November 2015 / Accepted: 25 November 2015 / Published: 2 December 2015
(This article belongs to the Special Issue Oncolytic Viruses)
View Full-Text   |   Download PDF [263 KB, uploaded 2 December 2015]

Abstract

The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold. View Full-Text
Keywords: oncolytic virus; immunotherapy; reovirus; vaccinia; HSV; clinical trials oncolytic virus; immunotherapy; reovirus; vaccinia; HSV; clinical trials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Turnbull, S.; West, E.J.; Scott, K.J.; Appleton, E.; Melcher, A.; Ralph, C. Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? Viruses 2015, 7, 6291-6312.

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