Oncolytic Viruses
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (31 August 2015) | Viewed by 201129
Special Issue Editors
Interests: Oncolytic viruses, HSV-1, clinical trials, combination treatments, virus-induced immune response, tumor microenvironment
Special Issue Information
Dear Colleagues,
The concept that viruses can be employed as cancer therapeutics was already recognized in the early 1900s. Advances in our understanding of tumor and virus biology combined with developments in molecular techniques, led to a renewed interest in this field during the 1990’s. Oncolytic viruses based on engineered or naturally tumor-selective viral stains have now been the subject of a multitude of preclinical investigations and are making their way to clinical trials, with mounting evidence for safety and antitumor activity. Our understanding of their mechanism of action is rapidly growing and our view is shifting from viruses as direct tumor cell lysing agents to immune stimulating oncolytic vaccines.
This special issue of Viruses is dedicated to the use of these agents in cancer therapy. We hope to assemble a collection of research papers and reviews that together will offer a comprehensive view on this promising field, which reflects our current understanding and looks toward the future. Topics may include studies on improving oncolytic viral vectors, manipulating the virus induced immune response, role of the tumor microenvironment, mechanisms of virus-mediated cell death, viral delivery and imaging techniques, lessons from clinical trials and personalized viral therapy.
We hope this work will enrich our current understanding of oncolytic virus therapy and aid the research community in the development and clinical translation of effective virus-based anti-cancer therapies.
Prof. E. Antonio Chiocca
Dr. Martine L.M. Lamfers
Guest Editors
Manuscript Submission Information
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Keywords
- virotherapy
- oncolytic viruses
- oncolytic vaccines
- virus genetic engineering
- oncolytic cell killing mechanisms
- virus-microenvironment interaction
- virus-induced immune response
- viro-immunotherapy
- virus delivery and imaging
- combination therapy