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Viruses 2015, 7(10), 5172-5190; doi:10.3390/v7102867

Filoviruses: One of These Things is (not) Like the Other

1
Immunology Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
University of New Mexico, Center for Global Health, Department of Internal Medicine
*
Author to whom correspondence should be addressed.
Academic Editor: Jens H. Kuhn
Received: 6 August 2015 / Revised: 15 September 2015 / Accepted: 16 September 2015 / Published: 29 September 2015
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
View Full-Text   |   Download PDF [256 KB, uploaded 29 September 2015]

Abstract

The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus pathogenesis. However, in comparison, the seven other known filovirus family members are significantly understudied. Many of these, including Marburgviruses and Ebolaviruses other than EBOV, are also highly virulent and fully capable of causing widespread epidemics. This review places the focus on these non-EBOV filoviruses, including known immunological and pathological data. The available animal models, research tools and currently available therapeutics will also be discussed along with an emphasis in the large number of current gaps in knowledge of these less highlighted filoviruses. It is evident that much research is yet to be done in order to bring the non-EBOV filovirus field to the forefront of current research and, importantly, to the development of more effective vaccines and therapeutics to combat potential future outbreaks. View Full-Text
Keywords: Ebola; Ebolavirus; Marburg; Marburgvirus; Filoviridae; filovirus; hemorrhagic; animal models; correlates of immunity Ebola; Ebolavirus; Marburg; Marburgvirus; Filoviridae; filovirus; hemorrhagic; animal models; correlates of immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Anthony, S.M.; Bradfute, S.B. Filoviruses: One of These Things is (not) Like the Other. Viruses 2015, 7, 5172-5190.

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