HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
AbstractEukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication. View Full-Text
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Guerrero, S.; Batisse, J.; Libre, C.; Bernacchi, S.; Marquet, R.; Paillart, J.-C. HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus. Viruses 2015, 7, 199-218.
Guerrero S, Batisse J, Libre C, Bernacchi S, Marquet R, Paillart J-C. HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus. Viruses. 2015; 7(1):199-218.Chicago/Turabian Style
Guerrero, Santiago; Batisse, Julien; Libre, Camille; Bernacchi, Serena; Marquet, Roland; Paillart, Jean-Christophe. 2015. "HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus." Viruses 7, no. 1: 199-218.