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Viruses 2014, 6(9), 3563-3583; doi:10.3390/v6093563

The Adenovirus Genome Contributes to the Structural Stability of the Virion

1,2,3
,
1,2,3
and
1,2,3,4,*
1
Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada
2
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
3
Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
4
Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
*
Author to whom correspondence should be addressed.
Received: 31 July 2014 / Revised: 15 September 2014 / Accepted: 17 September 2014 / Published: 24 September 2014
(This article belongs to the Special Issue Adenoviral Vectors)
View Full-Text   |   Download PDF [650 KB, uploaded 12 May 2015]   |  

Abstract

Adenovirus (Ad) vectors are currently the most commonly used platform for therapeutic gene delivery in human gene therapy clinical trials. Although these vectors are effective, many researchers seek to further improve the safety and efficacy of Ad-based vectors through detailed characterization of basic Ad biology relevant to its function as a vector system. Most Ad vectors are deleted of key, or all, viral protein coding sequences, which functions to not only prevent virus replication but also increase the cloning capacity of the vector for foreign DNA. However, radical modifications to the genome size significantly decreases virion stability, suggesting that the virus genome plays a role in maintaining the physical stability of the Ad virion. Indeed, a similar relationship between genome size and virion stability has been noted for many viruses. This review discusses the impact of the genome size on Ad virion stability and emphasizes the need to consider this aspect of virus biology in Ad-based vector design. View Full-Text
Keywords: Adenovirus; virion stability; viral vectors; helper-dependent Ad Adenovirus; virion stability; viral vectors; helper-dependent Ad
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Saha, B.; Wong, C.M.; Parks, R.J. The Adenovirus Genome Contributes to the Structural Stability of the Virion. Viruses 2014, 6, 3563-3583.

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