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Reply published on 12 September 2014, see Viruses 2014, 6(9), 3425-3427.

Comment of Viruses 2014, 6(2), 524-534.

Open AccessComment
Viruses 2014, 6(9), 3415-3424; https://doi.org/10.3390/v6093415

Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom

1
National Reference Centre for Hantavirus Infections, Laboratory of Clinical Virology, University Hospitals Gasthuisberg, Leuven, 3000, Belgium
2
Janssen, Pharmaceutical Companies of Johnson & Johnson, Beerse, 2340, Belgium
*
Author to whom correspondence should be addressed.
Received: 10 July 2014 / Revised: 25 August 2014 / Accepted: 26 August 2014 / Published: 12 September 2014
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Abstract

This British hantavirus IgG prevalence study, aimed at 119 asymptomatic farmers in England, and using indirect immunofluorescence assay (IFA) as screening technique, concluded that rat-transmitted Seoul virus (SEOV) might be the main suspect as hantaviral pathogen in the UK. Exactly the same conclusion, using the same IFA screening technique, resulted from a 1994 serosurvey in the same country, and in 627 clinical cases plus 100 healthy controls. SEOV-positive study subjects were also mainly farmers with heavy rat-exposure, but residing in Northern-Ireland, a region where all other known rodent reservoirs for pathogenic hantaviruses are known to be absent, except the wild rat. A rodent capture action in and around the farms of eight seropositives confirmed SEOV seropositivity in 21.6% of 51 rats. All SEOV seropositives were patients, hospitalized with an acute feverish condition, a majority of which having the clinical picture of hantavirus-induced nephropathy, known as hemorrhagic fever with renal syndrome (HFRS). Leptospirosis, often mimicking perfectly HFRS, was serologically excluded. Thus, SEOV was established as a human hantaviral pathogen in the UK and in Europe 20 years ago. View Full-Text
Keywords: Seoul virus (SEOV); hantavirus; wild rat; prevalence; risk factors; hemorrhagic fever with renal syndrome (HFRS); U.K.; Northern Ireland Seoul virus (SEOV); hantavirus; wild rat; prevalence; risk factors; hemorrhagic fever with renal syndrome (HFRS); U.K.; Northern Ireland
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Clement, J.; McKenna, P.; Vergote, V.; Van Ranst, M. Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom. Viruses 2014, 6, 3415-3424.

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