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Evolution of Specific Antibodies and Proviral DNA in Milk of Small Ruminants Infected by Small Ruminant Lentivirus
Viruses 2014, 6(8), 3311-3333; doi:10.3390/v6083311

Immunogenetics of Small Ruminant Lentiviral Infections

1 Centre for the Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada 2 Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
* Author to whom correspondence should be addressed.
Received: 23 May 2014 / Revised: 18 August 2014 / Accepted: 19 August 2014 / Published: 22 August 2014
(This article belongs to the Special Issue Small Ruminant Lentiviruses)
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The small ruminant lentiviruses (SRLV) include the caprine arthritis encephalitis virus (CAEV) and the Maedi-Visna virus (MVV). Both of these viruses limit production and can be a major source of economic loss to producers. Little is known about how the immune system recognizes and responds to SRLVs, but due to similarities with the human immunodeficiency virus (HIV), HIV research can shed light on the possible immune mechanisms that control or lead to disease progression. This review will focus on the host immune response to HIV-1 and SRLV, and will discuss the possibility of breeding for enhanced SRLV disease resistance.
Keywords: SRLV; immune response; genetic selection SRLV; immune response; genetic selection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stonos, N.; Wootton, S.K.; Karrow, N. Immunogenetics of Small Ruminant Lentiviral Infections. Viruses 2014, 6, 3311-3333.

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