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Viruses 2014, 6(8), 2991-3018; doi:10.3390/v6082991

The Coronavirus Nucleocapsid Is a Multifunctional Protein

Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa
These authors contributed equally to this work.
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Received: 8 May 2014 / Revised: 9 July 2014 / Accepted: 11 July 2014 / Published: 7 August 2014
(This article belongs to the Section Animal Viruses)
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Abstract

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein. View Full-Text
Keywords: nucleocapsid protein; coronavirus assembly; coronavirus N; intracellular localization; protein topology nucleocapsid protein; coronavirus assembly; coronavirus N; intracellular localization; protein topology
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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McBride, R.; van Zyl, M.; Fielding, B.C. The Coronavirus Nucleocapsid Is a Multifunctional Protein. Viruses 2014, 6, 2991-3018.

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