Next Article in Journal
Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora
Next Article in Special Issue
Fitness Impaired Drug Resistant HIV-1 Is Not Compromised in Cell-to-Cell Transmission or Establishment of and Reactivation from Latency
Previous Article in Journal
Dysregulated microRNA Expression in Serum of Non-Vaccinated Children with Varicella
Previous Article in Special Issue
HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies
Article Menu

Export Article

Open AccessReview
Viruses 2014, 6(4), 1837-1860; doi:10.3390/v6041837

HIV-1 Latency in Monocytes/Macrophages

UPRES EA4266, SFR FED 4234, Pathogens and Inflammation Laboratory, Department of Virology, CHRU Besançon, University of Franche-Comte, F-25030 Besançon, France
*
Author to whom correspondence should be addressed.
Received: 2 January 2014 / Revised: 11 March 2014 / Accepted: 28 March 2014 / Published: 22 April 2014
(This article belongs to the Special Issue HIV Latency)
View Full-Text   |   Download PDF [971 KB, uploaded 12 May 2015]   |  

Abstract

Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been established called the HIV-1 reservoir. Highly active antiretroviral therapy (HAART) has significantly improved the life of HIV-1 infected patients. However, complete eradication of HIV-1 from infected individuals is not possible without targeting latent sources of infection. HIV-1 establishes latent infection in resting CD4+ T cells and findings indicate that latency can also be established in the cells of monocyte/macrophage lineage. Monocyte/macrophage lineage includes among others, monocytes, macrophages and brain resident macrophages. These cells are relatively more resistant to apoptosis induced by HIV-1, thus are important stable hideouts of the virus. Much effort has been made in the direction of eliminating HIV-1 resting CD4+ T-cell reservoirs. However, it is impossible to achieve a cure for HIV-1 without considering these neglected latent reservoirs, the cells of monocyte/macrophage lineage. In this review we will describe our current understanding of the mechanism of latency in monocyte/macrophage lineage and how such cells can be specifically eliminated from the infected host. View Full-Text
Keywords: HIV-1; latency; monocytes; macrophages; microglial cells HIV-1; latency; monocytes; macrophages; microglial cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kumar, A.; Abbas, W.; Herbein, G. HIV-1 Latency in Monocytes/Macrophages. Viruses 2014, 6, 1837-1860.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top