Viruses 2014, 6(4), 1715-1758; doi:10.3390/v6041715
Review

HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies

* email and email
Received: 2 January 2014; in revised form: 18 March 2014 / Accepted: 20 March 2014 / Published: 14 April 2014
(This article belongs to the Special Issue HIV Latency)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The major obstacle towards HIV-1 eradication is the life-long persistence of the virus in reservoirs of latently infected cells. In these cells the proviral DNA is integrated in the host’s genome but it does not actively replicate, becoming invisible to the host immune system and unaffected by existing antiviral drugs. Rebound of viremia and recovery of systemic infection that follows interruption of therapy, necessitates life-long treatments with problems of compliance, toxicity, and untenable costs, especially in developing countries where the infection hits worst. Extensive research efforts have led to the proposal and preliminary testing of several anti-latency compounds, however, overall, eradication strategies have had, so far, limited clinical success while posing several risks for patients. This review will briefly summarize the more recent advances in the elucidation of mechanisms that regulates the establishment/maintenance of latency and therapeutic strategies currently under evaluation in order to eradicate HIV persistence.
Keywords: HIV; latency; mechanisms of latency; reactivating compounds; immune therapy
PDF Full-text Download PDF Full-Text [2110 KB, Updated Version, uploaded 17 April 2014 09:52 CEST]
The original version is still available [2117 KB, uploaded 14 April 2014 15:13 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Battistini, A.; Sgarbanti, M. HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies. Viruses 2014, 6, 1715-1758.

AMA Style

Battistini A, Sgarbanti M. HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies. Viruses. 2014; 6(4):1715-1758.

Chicago/Turabian Style

Battistini, Angela; Sgarbanti, Marco. 2014. "HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies." Viruses 6, no. 4: 1715-1758.


Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert