Viruses 2014, 6(3), 1442-1453; doi:10.3390/v6031442
Article

Retrospective Serology Study of Respiratory Virus Infections in Captive Great Apes

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Received: 23 December 2013; in revised form: 14 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Animal Viruses)
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Abstract: Great apes are extremely sensitive to infections with human respiratory viruses. In this study, we retrospectively analyzed sera from captive chimpanzees, gorillas and orang-utans. More than 1000 sera (403 chimpanzee, 77 gorilla, and 535 orang-utan sera) were analyzed for antibodies to the human respiratory viruses RSV (respiratory syncytial virus, hMPV (human metapneumovirus), H1N1 and H3N2 influenza A viruses, and influenza B virus. In all ape species high seroprevalences were found for RSV, hMPV, and influenza B virus. A high percentage of captive chimpanzees also showed evidence of influenza A H1N1 infections, and had low levels of H3N2 antibodies, while in sera from gorillas and orang-utans antibody levels to influenza A and B viruses were much lower or practically absent. Transmission of respiratory viruses was examined in longitudinal sera of young chimpanzees, and in chimpanzee sera taken during health checks. In young animals isolated cases of influenza infections were monitored, but evidence was found for single introductions followed by a rapid dissemination of RSV and hMPV within the group. Implementation of strict guidelines for handling and housing of nonhuman primates was shown to be an efficient method to reduce the introduction of respiratory infections in colonies of captive animals. RSV seroprevalence rates of chimpanzees remained high, probably due to circulating virus in the chimpanzee colony.
Keywords: respiratory viruses; great apes; serology; anthroponotic infections
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Buitendijk, H.; Fagrouch, Z.; Niphuis, H.; Bogers, W.M.; Warren, K.S.; Verschoor, E.J. Retrospective Serology Study of Respiratory Virus Infections in Captive Great Apes. Viruses 2014, 6, 1442-1453.

AMA Style

Buitendijk H, Fagrouch Z, Niphuis H, Bogers WM, Warren KS, Verschoor EJ. Retrospective Serology Study of Respiratory Virus Infections in Captive Great Apes. Viruses. 2014; 6(3):1442-1453.

Chicago/Turabian Style

Buitendijk, Hester; Fagrouch, Zahra; Niphuis, Henk; Bogers, Willy M.; Warren, Kristin S.; Verschoor, Ernst J. 2014. "Retrospective Serology Study of Respiratory Virus Infections in Captive Great Apes." Viruses 6, no. 3: 1442-1453.


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