Viruses 2014, 6(3), 1365-1378; doi:10.3390/v6031365
Super-Resolution Microscopy: A Virus’ Eye View of the Cell
Institute of Immunity and Transplantation, University College London, London NW3 2PF, UK
Received: 13 January 2014 / Revised: 1 March 2014 / Accepted: 11 March 2014 / Published: 19 March 2014
(This article belongs to the Special Issue Viruses and Tetraspanins)
Abstract
It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and cell biology. This article provides an introduction to super-resolution imaging; in particular, localisation microscopy, and explores the application of such technologies to the study of viruses and tetraspanins, the topic of this special issue. View Full-TextKeywords:
microscopy; super-resolution; PALM; STORM; dSTORM; tetraspanin; virus assembly; virus entry
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MDPI and ACS Style
Grove, J. Super-Resolution Microscopy: A Virus’ Eye View of the Cell. Viruses 2014, 6, 1365-1378.