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Viruses 2014, 6(3), 1365-1378; doi:10.3390/v6031365

Super-Resolution Microscopy: A Virus’ Eye View of the Cell

Institute of Immunity and Transplantation, University College London, London NW3 2PF, UK
Received: 13 January 2014 / Revised: 1 March 2014 / Accepted: 11 March 2014 / Published: 19 March 2014
(This article belongs to the Special Issue Viruses and Tetraspanins)
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Abstract

It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and cell biology. This article provides an introduction to super-resolution imaging; in particular, localisation microscopy, and explores the application of such technologies to the study of viruses and tetraspanins, the topic of this special issue.
Keywords: microscopy; super-resolution; PALM; STORM; dSTORM; tetraspanin; virus assembly; virus entry microscopy; super-resolution; PALM; STORM; dSTORM; tetraspanin; virus assembly; virus entry
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Grove, J. Super-Resolution Microscopy: A Virus’ Eye View of the Cell. Viruses 2014, 6, 1365-1378.

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