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Viruses 2014, 6(2), 752-781; doi:10.3390/v6020752

Experimental Infections of Wild Birds with West Nile Virus

Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos (Madrid), 28130, Spain
Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 4 February 2014 / Accepted: 4 February 2014 / Published: 13 February 2014
(This article belongs to the Section Animal Viruses)
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Avian models of West Nile virus (WNV) disease have become pivotal in the study of infection pathogenesis and transmission, despite the intrinsic constraints that represents this type of experimental research that needs to be conducted in biosecurity level 3 (BSL3) facilities. This review summarizes the main achievements of WNV experimental research carried out in wild birds, highlighting advantages and limitations of this model. Viral and host factors that determine the infection outcome are analyzed in detail, as well as recent discoveries about avian immunity, viral transmission, and persistence achieved through experimental research. Studies of laboratory infections in the natural host will help to understand variations in susceptibility and reservoir competence among bird species, as well as in the epidemiological patterns found in different affected areas. View Full-Text
Keywords: West Nile virus; wild birds; experimental infection; pathogenesis; transmission; immunity; host competence West Nile virus; wild birds; experimental infection; pathogenesis; transmission; immunity; host competence

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pérez-Ramírez, E.; Llorente, F.; Jiménez-Clavero, M.Á. Experimental Infections of Wild Birds with West Nile Virus. Viruses 2014, 6, 752-781.

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