Next Article in Journal
Apple Latent Spherical Virus Vector as Vaccine for the Prevention and Treatment of Mosaic Diseases in Pea, Broad Bean, and Eustoma Plants by Bean Yellow Mosaic Virus
Previous Article in Journal
PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA
Previous Article in Special Issue
Current Perspectives on HIV-1 Antiretroviral Drug Resistance
Article Menu

Export Article

Open AccessReview
Viruses 2014, 6(11), 4227-4241; doi:10.3390/v6114227

Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding

1
Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada
2
Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, QC H3G 1Y6, Canada
3
Department of Medicine, Division of Experimental Medicine, McGill University, 1110 Pine Avenue West, Montreal, QC H3A 1A3, Canada
Present Address: Department of Medical Microbiology and Immunology, University of Alberta, 6-020 Katz Group Centre, Edmonton, AB T6G 2E1, Canada.
*
Author to whom correspondence should be addressed.
Received: 27 August 2014 / Revised: 22 October 2014 / Accepted: 22 October 2014 / Published: 6 November 2014
(This article belongs to the Special Issue HIV Drug Resistance)
View Full-Text   |   Download PDF [1123 KB, uploaded 12 May 2015]   |  

Abstract

Direct-acting antivirals (DAAs) have significantly improved the treatment of infection with the hepatitis C virus. A promising class of novel antiviral agents targets the HCV NS5A protein. The high potency and broad genotypic coverage are favorable properties. NS5A inhibitors are currently assessed in advanced clinical trials in combination with viral polymerase inhibitors and/or viral protease inhibitors. However, the clinical use of NS5A inhibitors is also associated with new challenges. HCV variants with decreased susceptibility to these drugs can emerge and compromise therapy. In this review, we discuss resistance patterns in NS5A with focus prevalence and implications for inhibitor binding. View Full-Text
Keywords: Daclatasvir; NS5A; HCV; resistance; resistance barrier; viral fitness; DAA Daclatasvir; NS5A; HCV; resistance; resistance barrier; viral fitness; DAA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Issur, M.; Götte, M. Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding. Viruses 2014, 6, 4227-4241.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top