Next Article in Journal
Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding
Next Article in Special Issue
Twenty Years of KSHV
Previous Article in Journal
Cytoplasmic Dynein Promotes HIV-1 Uncoating
Previous Article in Special Issue
Epidemiology and Transmission of Kaposi’s Sarcoma-Associated Herpesvirus
Article Menu

Export Article

Open AccessReview
Viruses 2014, 6(11), 4212-4226; doi:10.3390/v6114212

PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA

Department of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA
*
Author to whom correspondence should be addressed.
Received: 9 September 2014 / Revised: 23 October 2014 / Accepted: 24 October 2014 / Published: 4 November 2014
(This article belongs to the Special Issue Kaposi's Sarcoma-Associated Herpesvirus)
View Full-Text   |   Download PDF [611 KB, uploaded 12 May 2015]   |  

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesivrus, the causative agent of Kaposi’s sarcoma and body cavity lymphomas. During infection KSHV produces a highly abundant long non-coding polyadenylated RNA that is retained in the nucleus known as PAN RNA. Long noncoding RNAs (lncRNA) are key regulators of gene expression and are known to interact with specific chromatin modification complexes, working in cis and trans to regulate gene expression. Data strongly supports a model where PAN RNA is a multifunctional regulatory transcript that controls KSHV gene expression by mediating the modification of chromatin by targeting the KSHV repressed genome. View Full-Text
Keywords: Kaposi’s sarcoma-associated herpesvirus (KSHV); gammaherpesvirus; long noncoding RNA; PAN; histone modification; chromatin; epigenetics; gene expression Kaposi’s sarcoma-associated herpesvirus (KSHV); gammaherpesvirus; long noncoding RNA; PAN; histone modification; chromatin; epigenetics; gene expression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rossetto, C.C.; Pari, G.S. PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA. Viruses 2014, 6, 4212-4226.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top