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Viruses 2013, 5(1), 182-191; doi:10.3390/v5010182
Review

Insights into the Roles of Cyclophilin A During Influenza Virus Infection

,
 and *
Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
* Author to whom correspondence should be addressed.
Received: 22 November 2012 / Revised: 22 December 2012 / Accepted: 9 January 2013 / Published: 15 January 2013
(This article belongs to the Special Issue Cyclophilins and Viruses)
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Abstract

Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
Keywords: influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, X.; Zhao, Z.; Liu, W. Insights into the Roles of Cyclophilin A During Influenza Virus Infection. Viruses 2013, 5, 182-191.

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