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Insights into the Roles of Cyclophilin A During Influenza Virus Infection
Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
* Author to whom correspondence should be addressed.
Received: 22 November 2012; in revised form: 22 December 2012 / Accepted: 9 January 2013 / Published: 15 January 2013
Abstract: Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
Keywords: influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction
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Cite This Article
MDPI and ACS Style
Liu, X.; Zhao, Z.; Liu, W. Insights into the Roles of Cyclophilin A During Influenza Virus Infection. Viruses 2013, 5, 182-191.
Liu X, Zhao Z, Liu W. Insights into the Roles of Cyclophilin A During Influenza Virus Infection. Viruses. 2013; 5(1):182-191.
Liu, Xiaoling; Zhao, Zhendong; Liu, Wenjun. 2013. "Insights into the Roles of Cyclophilin A During Influenza Virus Infection." Viruses 5, no. 1: 182-191.