Viruses 2012, 4(9), 1372-1389; doi:10.3390/v4091372
Article

Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats: A Natural Model of Lentivirus-Induced Renal Disease Changes

1email, 2email, 3email and 4,* email
Received: 18 July 2012; in revised form: 15 August 2012 / Accepted: 16 August 2012 / Published: 27 August 2012
(This article belongs to the Special Issue Feline Retroviruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Human immunodeficiency virus (HIV) is associated with several renal syndromes including acute and chronic renal failures, but the underlying pathogenic mechanisms are unclear. HIV and feline immunodeficiency virus (FIV) share numerous biological and pathological features, including renal alterations. We investigated and compared the morphological changes of renal tissue of 51 experimentally and 21 naturally infected cats. Compared to the latter, the experimentally infected cats exhibited some mesangial widening and glomerulonephritis, milder proteinuria, and lower tubular and interstitial alterations. The numbers of giant protein tubular casts and tubular microcysts were also lower. In contrast, diffuse interstitial infiltrates and glomerular and interstitial amyloidosis were detected only in naturally infected cats. Similar alterations are found in HIV infected patients, thus supporting the idea of a causative role of FIV infection in renal disease, and underlining the relevance of the FIV and its natural host as an animal model for investigating lentivirus-associated nephropathy.
Keywords: cat; feline immunodeficiency virus; FIV; kidney diseases; renal pathology
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MDPI and ACS Style

Poli, A.; Tozon, N.; Guidi, G.; Pistello, M. Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats: A Natural Model of Lentivirus-Induced Renal Disease Changes. Viruses 2012, 4, 1372-1389.

AMA Style

Poli A, Tozon N, Guidi G, Pistello M. Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats: A Natural Model of Lentivirus-Induced Renal Disease Changes. Viruses. 2012; 4(9):1372-1389.

Chicago/Turabian Style

Poli, Alessandro; Tozon, Natasa; Guidi, Grazia; Pistello, Mauro. 2012. "Renal Alterations in Feline Immunodeficiency Virus (FIV)-Infected Cats: A Natural Model of Lentivirus-Induced Renal Disease Changes." Viruses 4, no. 9: 1372-1389.


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