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Nuclear Actin and Lamins in Viral Infections
Charles University in Prague, Faculty of Science, Department of Genetics and Microbiology, Vinicna 5, 12844, Prague 2, Czech Republic
* Author to whom correspondence should be addressed.
Received: 24 January 2012; in revised form: 20 February 2012 / Accepted: 21 February 2012 / Published: 28 February 2012
Abstract: Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription. Nuclear actin is now widely accepted to be another cytoskeletal protein present in the nucleus that fulfills important functions in the gene expression. Some viruses replicating in the nucleus evolved the ability to interact with and probably utilize nuclear actin for their replication, e.g., for the assembly and transport of capsids or mRNA export. On the other hand, lamins play a role in the propagation of other viruses since nuclear lamina may represent a barrier for virions entering or escaping the nucleus. This review will summarize the current knowledge about the roles of nuclear actin and lamins in viral infections.
Keywords: viruses; nuclear actin; nuclear lamina; lamin; cytoskeleton; nucleus
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Cibulka, J.; Fraiberk, M.; Forstova, J. Nuclear Actin and Lamins in Viral Infections. Viruses 2012, 4, 325-347.
Cibulka J, Fraiberk M, Forstova J. Nuclear Actin and Lamins in Viral Infections. Viruses. 2012; 4(3):325-347.
Cibulka, Jakub; Fraiberk, Martin; Forstova, Jitka. 2012. "Nuclear Actin and Lamins in Viral Infections." Viruses 4, no. 3: 325-347.