Viruses 2012, 4(12), 3551-3571; doi:10.3390/v4123551

Human Metapneumovirus Antagonism of Innate Immune Responses

1email, 1email and 1,2,3,* email
Received: 1 November 2012; in revised form: 20 November 2012 / Accepted: 30 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family, which includes several major human and animal pathogens. Epidemiological studies indicate that hMPV is a significant human respiratory pathogen with worldwide distribution. It is associated with respiratory illnesses in children, adults, and immunocompromised patients, ranging from upper respiratory tract infections to severe bronchiolitis and pneumonia. Interferon (IFN) represents a major line of defense against virus infection, and in response, viruses have evolved countermeasures to inhibit IFN production as well as IFN signaling. Although the strategies of IFN evasion are similar, the specific mechanisms by which paramyxoviruses inhibit IFN responses are quite diverse. In this review, we will present an overview of the strategies that hMPV uses to subvert cellular signaling in airway epithelial cells, the major target of infection, as well as in primary immune cells.
Keywords: metapneumovirus; viral proteins; innate immune system; interferon antagonism
PDF Full-text Download PDF Full-Text [920 KB, uploaded 7 December 2012 12:05 CET]

Export to BibTeX |

MDPI and ACS Style

Kolli, D.; Bao, X.; Casola, A. Human Metapneumovirus Antagonism of Innate Immune Responses. Viruses 2012, 4, 3551-3571.

AMA Style

Kolli D, Bao X, Casola A. Human Metapneumovirus Antagonism of Innate Immune Responses. Viruses. 2012; 4(12):3551-3571.

Chicago/Turabian Style

Kolli, Deepthi; Bao, Xiaoyong; Casola, Antonella. 2012. "Human Metapneumovirus Antagonism of Innate Immune Responses." Viruses 4, no. 12: 3551-3571.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert