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Viruses 2012, 4(12), 3551-3571; doi:10.3390/v4123551
Review

Human Metapneumovirus Antagonism of Innate Immune Responses

1
, 1
 and 1,2,3,*
Received: 1 November 2012; in revised form: 20 November 2012 / Accepted: 30 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
View Full-Text   |   Download PDF [920 KB, uploaded 7 December 2012]
Abstract: Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family, which includes several major human and animal pathogens. Epidemiological studies indicate that hMPV is a significant human respiratory pathogen with worldwide distribution. It is associated with respiratory illnesses in children, adults, and immunocompromised patients, ranging from upper respiratory tract infections to severe bronchiolitis and pneumonia. Interferon (IFN) represents a major line of defense against virus infection, and in response, viruses have evolved countermeasures to inhibit IFN production as well as IFN signaling. Although the strategies of IFN evasion are similar, the specific mechanisms by which paramyxoviruses inhibit IFN responses are quite diverse. In this review, we will present an overview of the strategies that hMPV uses to subvert cellular signaling in airway epithelial cells, the major target of infection, as well as in primary immune cells.
Keywords: metapneumovirus; viral proteins; innate immune system; interferon antagonism metapneumovirus; viral proteins; innate immune system; interferon antagonism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kolli, D.; Bao, X.; Casola, A. Human Metapneumovirus Antagonism of Innate Immune Responses. Viruses 2012, 4, 3551-3571.

AMA Style

Kolli D, Bao X, Casola A. Human Metapneumovirus Antagonism of Innate Immune Responses. Viruses. 2012; 4(12):3551-3571.

Chicago/Turabian Style

Kolli, Deepthi; Bao, Xiaoyong; Casola, Antonella. 2012. "Human Metapneumovirus Antagonism of Innate Immune Responses." Viruses 4, no. 12: 3551-3571.


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