Viruses 2012, 4(12), 3494-3510; doi:10.3390/v4123494

The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection

1,* email, 1email, 1email, 2email and 1email
Received: 7 November 2012; in revised form: 28 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host—pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and its use as a model of disease, most notably for explorations of virus infection and allergic airways disease, for vaccine evaluation, and for the development of immunomodulatory strategies for acute respiratory virus infection.
Keywords: PVM; inflammation; leukocytes; eosinophils; respiratory syncytial virus; RSV; TLR; IFN; heterologous immunity; MIP-1α
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MDPI and ACS Style

Dyer, K.D.; Garcia-Crespo, K.E.; Glineur, S.; Domachowske, J.B.; Rosenberg, H.F. The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection. Viruses 2012, 4, 3494-3510.

AMA Style

Dyer KD, Garcia-Crespo KE, Glineur S, Domachowske JB, Rosenberg HF. The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection. Viruses. 2012; 4(12):3494-3510.

Chicago/Turabian Style

Dyer, Kimberly D.; Garcia-Crespo, Katia E.; Glineur, Stephanie; Domachowske, Joseph B.; Rosenberg, Helene F. 2012. "The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection." Viruses 4, no. 12: 3494-3510.

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