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Viruses 2012, 4(12), 3389-3419; doi:10.3390/v4123389
Review

Prion Disease and the Innate Immune System

 and *
Received: 6 October 2012; in revised form: 14 November 2012 / Accepted: 22 November 2012 / Published: 28 November 2012
(This article belongs to the Special Issue Recent Developments in the Prion Field)
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Abstract: Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious quality that thrives in immune-competent hosts. While much has been discovered about the routing and critical components involved in the peripheral pathogenesis of these agents there are still many aspects to be discovered. Research into this area has been extensive as it represents a major target for therapeutic intervention within this group of diseases. The main focus of pathological damage in these diseases occurs within the central nervous system. Cells of the innate immune system have been proven to be critical players in the initial pathogenesis of prion disease, and may have a role in the pathological progression of disease. Understanding how prions interact with the host innate immune system may provide us with natural pathways and mechanisms to combat these diseases prior to their neuroinvasive stage. We present here a review of the current knowledge regarding the role of the innate immune system in prion pathogenesis.
Keywords: prion disease pathogenesis; transmissible spongiform encephalopathy; innate immune system prion disease pathogenesis; transmissible spongiform encephalopathy; innate immune system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bradford, B.M.; Mabbott, N.A. Prion Disease and the Innate Immune System. Viruses 2012, 4, 3389-3419.

AMA Style

Bradford BM, Mabbott NA. Prion Disease and the Innate Immune System. Viruses. 2012; 4(12):3389-3419.

Chicago/Turabian Style

Bradford, Barry M.; Mabbott, Neil A. 2012. "Prion Disease and the Innate Immune System." Viruses 4, no. 12: 3389-3419.



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