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Viruses 2012, 4(11), 3090-3108; doi:10.3390/v4113090
Review

Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines

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Received: 28 September 2012; in revised form: 5 November 2012 / Accepted: 7 November 2012 / Published: 14 November 2012
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Abstract: The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and “universal” anti-influenza vaccines.
Keywords: monoclonal antibody; protective epitopes; heterosubtipic neutralizing activity; epitope-based influenza vaccine monoclonal antibody; protective epitopes; heterosubtipic neutralizing activity; epitope-based influenza vaccine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Clementi, N.; Criscuolo, E.; Castelli, M.; Mancini, N.; Clementi, M.; Burioni, R. Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines. Viruses 2012, 4, 3090-3108.

AMA Style

Clementi N, Criscuolo E, Castelli M, Mancini N, Clementi M, Burioni R. Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines. Viruses. 2012; 4(11):3090-3108.

Chicago/Turabian Style

Clementi, Nicola; Criscuolo, Elena; Castelli, Matteo; Mancini, Nicasio; Clementi, Massimo; Burioni, Roberto. 2012. "Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines." Viruses 4, no. 11: 3090-3108.


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