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Viruses 2012, 4(11), 2766-2785; doi:10.3390/v4112766

Immune Responses and Lassa Virus Infection

1 Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, 21 avenue Tony Garnier, 69365 Lyon, France 2 Laboratoire P4 Jean Mérieux-Inserm, 21 avenue Tony Garnier, 69365 Lyon, France
* Author to whom correspondence should be addressed.
Received: 30 September 2012 / Revised: 23 October 2012 / Accepted: 31 October 2012 / Published: 5 November 2012
(This article belongs to the Special Issue Arenaviruses)
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Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently been made, through the use of in vitro human models and nonhuman primates, the only relevant animal model that mimics the pathophysiology and immune responses induced in patients. We discuss here the roles of the various components of the innate and adaptive immune systems in Lassa virus infection and in the control of viral replication and pathogenesis.
Keywords: Lassa virus; hemorrhagic fever; T-cell responses; antigen-presenting cells; immunity Lassa virus; hemorrhagic fever; T-cell responses; antigen-presenting cells; immunity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Russier, M.; Pannetier, D.; Baize, S. Immune Responses and Lassa Virus Infection. Viruses 2012, 4, 2766-2785.

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