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Viruses 2011, 3(9), 1757-1776; doi:10.3390/v3091757
Review

How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission

1,2
, 1,2
 and 1,2,3,*
Received: 8 July 2011; in revised form: 26 August 2011 / Accepted: 30 August 2011 / Published: 15 September 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
Download PDF [2443 KB, uploaded 15 September 2011]
Abstract: Human immunodeficiency virus 1 (HIV-1) infects T cells, macrophages and dendritic cells and can manipulate their cytoskeleton structures at multiple steps during its replication cycle. Based on pharmacological and genetic targeting of cytoskeleton modulators, new imaging approaches and primary cell culture models, important roles for actin and microtubules during entry and cell-to-cell transfer have been established. Virological synapses and actin-containing membrane extensions can mediate HIV-1 transfer from dendritic cells or macrophage cells to T cells and between T cells. We will review the role of the cytoskeleton in HIV-1 entry, cellular trafficking and cell-to-cell transfer between primary cells.
Keywords: HIV-1; actin; microtubules; virological synapse; dendritic cells; cell-to-cell transfer HIV-1; actin; microtubules; virological synapse; dendritic cells; cell-to-cell transfer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lehmann, M.; Nikolic, D.S.; Piguet, V. How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission. Viruses 2011, 3, 1757-1776.

AMA Style

Lehmann M, Nikolic DS, Piguet V. How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission. Viruses. 2011; 3(9):1757-1776.

Chicago/Turabian Style

Lehmann, Martin; Nikolic, Damjan S.; Piguet, Vincent. 2011. "How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission." Viruses 3, no. 9: 1757-1776.


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