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How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission
Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva 1211, Switzerland
Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva 1211, Switzerland
Department of Dermatology and Wound Healing, Cardiff University School of Medicine and University Hospital of Wales, Cardiff, Wales, CF144XN, UK
* Author to whom correspondence should be addressed.
Received: 8 July 2011; in revised form: 26 August 2011 / Accepted: 30 August 2011 / Published: 15 September 2011
Abstract: Human immunodeficiency virus 1 (HIV-1) infects T cells, macrophages and dendritic cells and can manipulate their cytoskeleton structures at multiple steps during its replication cycle. Based on pharmacological and genetic targeting of cytoskeleton modulators, new imaging approaches and primary cell culture models, important roles for actin and microtubules during entry and cell-to-cell transfer have been established. Virological synapses and actin-containing membrane extensions can mediate HIV-1 transfer from dendritic cells or macrophage cells to T cells and between T cells. We will review the role of the cytoskeleton in HIV-1 entry, cellular trafficking and cell-to-cell transfer between primary cells.
Keywords: HIV-1; actin; microtubules; virological synapse; dendritic cells; cell-to-cell transfer
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Cite This Article
MDPI and ACS Style
Lehmann, M.; Nikolic, D.S.; Piguet, V. How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission. Viruses 2011, 3, 1757-1776.
Lehmann M, Nikolic DS, Piguet V. How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission. Viruses. 2011; 3(9):1757-1776.
Lehmann, Martin; Nikolic, Damjan S.; Piguet, Vincent. 2011. "How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission." Viruses 3, no. 9: 1757-1776.