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Viruses 2011, 3(12), 2462-2477; doi:10.3390/v3122462
Review

The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells

 and *
Received: 17 November 2011 / Revised: 7 December 2011 / Accepted: 15 December 2011 / Published: 21 December 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
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Abstract

Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection.
Keywords: polarized epithelium; actin cytoskeleton; tight junctions; virus entry polarized epithelium; actin cytoskeleton; tight junctions; virus entry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Delorme-Axford, E.; Coyne, C.B. The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells. Viruses 2011, 3, 2462-2477.

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