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Viruses 2011, 3(9), 1624-1633; doi:10.3390/v3091624
Commentary

Restricted Access to Myeloid Cells Explained

Received: 14 July 2011 / Revised: 24 August 2011 / Accepted: 27 August 2011 / Published: 5 September 2011
(This article belongs to the Section Editorial)
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Abstract

The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.
Keywords: Vpx; DCAF-1; SAMHD1; ubiquitin; Cullin4; HIV; SIV; macrophage; dendritic cell; myeloid cell Vpx; DCAF-1; SAMHD1; ubiquitin; Cullin4; HIV; SIV; macrophage; dendritic cell; myeloid cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Planelles, V. Restricted Access to Myeloid Cells Explained. Viruses 2011, 3, 1624-1633.

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