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Viruses 2011, 3(9), 1624-1633; doi:10.3390/v3091624

Restricted Access to Myeloid Cells Explained

Division of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Emma Eccles Jones Building, 15 North Medical Drive East 2100, Room 2520, Salt Lake City, UT 84112, USA
Received: 14 July 2011 / Revised: 24 August 2011 / Accepted: 27 August 2011 / Published: 5 September 2011
(This article belongs to the Section Editorial)
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Abstract

The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.
Keywords: Vpx; DCAF-1; SAMHD1; ubiquitin; Cullin4; HIV; SIV; macrophage; dendritic cell; myeloid cell Vpx; DCAF-1; SAMHD1; ubiquitin; Cullin4; HIV; SIV; macrophage; dendritic cell; myeloid cell
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Planelles, V. Restricted Access to Myeloid Cells Explained. Viruses 2011, 3, 1624-1633.

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