Next Article in Journal
Viral Determinants of HIV-1 Macrophage Tropism
Next Article in Special Issue
High Throughput Method to Quantify Anterior-Posterior Polarity of T-Cells and Epithelial Cells
Previous Article in Journal
N-Terminally Myristoylated Feline Foamy Virus Gag Allows Env-Independent Budding of Sub-Viral Particles
Viruses 2011, 3(11), 2238-2254; doi:10.3390/v3112238
Review

Hepatitis C Virus Assembly Imaging

1,* , 2
 and
2
Received: 21 September 2011 / Revised: 3 November 2011 / Accepted: 4 November 2011 / Published: 15 November 2011
(This article belongs to the Special Issue Frontiers in Imaging)
Download PDF [2030 KB, uploaded 12 May 2015]

Abstract

Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
Keywords: hepatitis C virus; virus assembly; cellular imaging hepatitis C virus; virus assembly; cellular imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Popescu, C.-I.; Rouillé, Y.; Dubuisson, J. Hepatitis C Virus Assembly Imaging. Viruses 2011, 3, 2238-2254.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert