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Hepatitis C Virus Assembly Imaging
Institute of Biochemistry, The Romanian Academy, Splaiul Independentei 296, 060031 Bucharest 17, Romania
Inserm U1019, CNRS UMR8204, Center for Infection and Immunity of Lille (CIIL), Institut Pasteur de Lille, Université Lille Nord de France, Lille 59021, France
* Author to whom correspondence should be addressed.
Received: 21 September 2011; in revised form: 3 November 2011 / Accepted: 4 November 2011 / Published: 15 November 2011
Abstract: Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
Keywords: hepatitis C virus; virus assembly; cellular imaging
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MDPI and ACS Style
Popescu, C.-I.; Rouillé, Y.; Dubuisson, J. Hepatitis C Virus Assembly Imaging. Viruses 2011, 3, 2238-2254.
Popescu C-I, Rouillé Y, Dubuisson J. Hepatitis C Virus Assembly Imaging. Viruses. 2011; 3(11):2238-2254.
Popescu, Costin-Ioan; Rouillé, Yves; Dubuisson, Jean. 2011. "Hepatitis C Virus Assembly Imaging." Viruses 3, no. 11: 2238-2254.